San Diego Padres vs Cleveland Guardians 3-22-22

San Diego Padres vs Cleveland Guardians 3/22/2022 Picks Predictions Previews

San Diego Padres vs Cleveland Guardians 3/22/2022 Picks Predictions Previews


The San Diego Padres will go against the Cleveland Guardians in MLB action in Goodyear Ballpark Goodyear, AZ, on Tuesday, March 22, 2022, at 4:05 PM ET.


San Diego was the greatest letdown of the 2021 season, owing to its promising 2020 season and subsequent tremendous offseason. With that considered, there are plenty of factors to be optimistic about them regaining their footing in 2022.


Fernando Tatis Jr. delivered an MVP performance. Manny Machado was his two-way, crafty self. Jake Cronenworth’s improvement progressed.


Every other aspect of this depth chart was only passable at best. Trent Grisham, Eric Hosmer, Tommy Pham, Wil Myers, and Austin Nola are among those named. What’s the good news? Those who return in 2022 can have even better results.


San Diego has as much talent as any club in the National League West. It’s all about execution this season, not falling off like they did last year.


With the Giants and Dodgers ready to lose several more matches, there are victories to be had without the Padres even boosting their 2021 victory total. The San Diego Padres have a new manager with a lot of experience and a loaded squad.


  • The Padres are 5-0 in their last 5 matches.
  • San Diego is 19-16 in their previous 35 road matches against the spread.
  • The totals went OVER in 17 of the Padres’ 38 last matches at home.

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San Diego Padres vs Cleveland Guardians Predictions 3/22/2022


The Cleveland Guardians are no longer in existence, in case you forgot. After being known as the Indians since 1915, they were renamed the Cleveland Guardians in July. Even though the Guardians’ eight-year unbeaten run came to an end in 2021, the team’s new owners believe the team will be able to compete for the AL Central crown in 2022.


The Guardians’ optimism will be bolstered if they can get back to full strength by the start of the season. Last season, Cleveland’s top three starters, Shane Bieber, Aaron Civale, and Zach Plesac, were all sidelined for large portions of the year, and the team finished second in the division with an 80–82 record.


In 2021, the squad was officially no-hit three times, a new high. They were no-hit for the fourth time in the second match of a seven-inning no-hitter against Tampa Bay, but MLB failed to notice. The nine-inning no-hitters were pitched by Chicago lefty Carlos Rodón,


Cincinnati left-hander Wade Miley, and Milwaukee’s Corbin Burnes and Josh Hader. Cleveland has no-hit 14 times in its existence as an American League original member, but never more than once in a season until this year.


  • The Indians are 3-2 in their last 5 matches.
  • Cleveland is 21-15 in their road matches against the spread.
  • The totals went OVER in 19 of the Indians’ 33 last matches at home.

San Diego Padres vs Cleveland Guardians. The MLB pick for this game is the Cleveland Guardians. Terry Francona, the team’s manager, had to withdraw from the season for the second year in a row due to health issues.


On July 29, Cleveland bench coach DeMarlo Hale took over as acting manager and led the team to a 30–33 record. The Cleveland Guardians will win to a predicted score of 12-7.


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San Diego Padres vs Cleveland Guardians 3/22/2022 Picks Predictions Previews

MLB Starting Time: 4:05 PM ET


Location: Goodyear Ballpark Goodyear, AZ


Date: Tuesday, March 22, 2022




MLB Odds: Cleveland Guardians -3.5


MLB Totals: 14.5


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