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San Francisco 49ers vs Tennessee Titans 12/23/2021 Picks Predictions Previews

San Francisco 49ers vs Tennessee Titans 12/23/2021 Picks Predictions Previews


The San Francisco 49ers and the Tennessee Titans will meet at the Nissan Stadium in Nashville, Tennessee on Thursday, December 23, 2021, at 8:20 PM ET. The 49ers are currently third in the NFC West standings with a record of 8-6.


San Francisco is entering this match with two straight wins. The team won over the Atlanta Falcons on Sunday to a score of 31-13. Jimmy Garoppolo ended with 235 yards with one touchdown on 23 dropbacks, averaging 9.8 yards per pass attempt. Jeff Wilson Jr. rolled up 110 yards on 21 carries and a score while Deebo Samuele added 29 yards and a score on the ground. 


The 49ers passed for 240.0 yards and rushed for 126.6 yards this season. Quarterback Jimmy Garoppolo has a total of 3,172 passing yards while running back Elijah Mitchell rushed for 759 total yards.


Wide receiver Deebo Samuel leads the receivers with 1,088 yards. Linebacker Fred Warner leads the team’s defense with 108 tackles and cornerback Jimmie Ward intercepted two passes for San Francisco.


  • The San Francisco 49ers are 1-7-1 ATS in their last 9 matches against Tennessee.
  • The 49ers are 8-3 SU in their last 11 matches against Tennessee.
  • The 49ers are 4-1 SU in their last 5 matches on the road against Tennessee.

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San Francisco 49ers vs Tennessee Titans Predictions 12/23/2021


The Tennessee Titans rank first in the AFC South standings this season, winning nine of their 14 matches. The Titans lost their match last Sunday against the Pittsburgh Steelers to a score of 13-19.


Ryan Tannehill committed two turnovers, an interception, and was sacked four times. Nick Westbrook-Ikhine caught four of his seven targets for just 32 yards while Anthony Firkser caught both his targets. Taylor Lewan surrendered one pressure while David Quessenberry surrendered seven pressures with two sacks.


The Titans passed for 202.8 yards and rushed for 142.3 yards. Quarterback Ryan Tannehill has a total of 3,118 passing yards while running back Derrick Henry rushed for 937 total yards.


Wide receiver A.J. Brown leads the receiving team with 615 yards. Safety Kevin Byard leads the team’s defense with 73 tackles and also made five interceptions. 


  • The total went OVER in 5 of Tennessee’s last 5 matches against San Francisco.
  • The Tennessee Titans are 5-1 SU in their last 6 matches at home.
  • The Titans are 1-4 SU in their last 5 matches at home against San Francisco.

San Francisco 49ers vs Tennessee Titans. The NFL’s pick is the San Francisco 49ers. San Francisco is the favored team here and the team has been playing well on the road.


The 49ers rank fourth in the league in rushing and are ninth place in total defense. San Francisco will manage to cover the nut here and win the game. Look for the San Francisco 49ers to win with a predicted score of 30-27.


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San Francisco 49ers vs Tennessee Titans 12/23/2021 Picks Predictions Previews

NFL Starting Time: 8:20 PM ET


Location: Nissan Stadium


Date: Thursday, December 23, 2021




NFL Odds: San Francisco 49ers -3.5


NFL Totals: 44.5


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