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San Francisco 49ers vs Jacksonville Jaguars 11/21/2021 Picks Predictions Previews

San Francisco 49ers vs Jacksonville Jaguars 11/21/2021 Picks Predictions Previews


The San Francisco 49ers will invade Tiaa Bank Field in Jacksonville, Florida to go against the Jacksonville Jaguars on Sunday, November 21, 2021, at 1:00 PM ET. The 49ers are currently third in the NFC West standings with an overall of 4-5.


San Francisco won over the Los Angeles Rams last Sunday to a score of 31-10. Jimmy Garoppolo completed 12 of 13 passes for 115 yards, finishing with only 20 dropbacks. Elijah Mitchell scurried with 27 carries and Jeff Wilson received 10. 


The 49ers passed for 244.3 yards and rushed for 117.9 yards this year. Quarterback Jimmy Garoppolo has a total of 1,936 passing yards and running back Elijah Mitchell rushed for 560 yards.


Wide receiver Deebo Samuel leads the receiving team with 979 yards while linebacker Fred Warner leads the team’s defense with 82 tackles. Cornerback Jimmie Ward intercepted two passes.


  • The San Francisco 49ers are 2-5 SU in their last 7 matches.
  • The 49ers are 4-1 ATS in their last 5 matches against Jacksonville.
  • The 49ers are 4-1 SU in their last 5 matches on the road.

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San Francisco 49ers vs Jacksonville Jaguars Predictions 11/21/2021


The Jacksonville Jaguars rank third in the AFC South standings with a record of 2-7. The team lost to the Indianapolis Colts to a score of 17-23. Trevor Lawrence struggled in the first half of the match and completed just three passes for 36 yards.


Lawrence finished with 162 passing yards in the second half. James Robinson carried the ball 12 times for 57 yards and a score. He also broke three tackles and gained 10 yards on three attempts.


The Jaguars passed for 213.7 yards and rushed for 119.0 yards. Quarterback Trevor Lawrence has a total of 1,983 passing yards and running back James Robinson rushed for 539 yards.


Wide receiver Marvin Jones Jr. leads the receivers with 434 yards and linebacker Damien Wilson leads the defensive unit with 64 tackles. Cornerback Nevin Lawson made one interception for the team.


  • The total went UNDER in 7 of Jacksonville’s last 8 matches.
  • The Jacksonville Jaguars are 2-18 SU in their last 20 matches.
  • The Jaguars are 2-10 SU in their last 12 matches at home.

San Francisco 49ers vs Jacksonville Jaguars. The NFL’s pick is the San Francisco 49ers. Jacksonville is struggling this year, rolling through the season with seven losses. Meanwhile, the 49ers bounced back last week against the Rams and ended with a huge victory.


San Francisco will easily dominate the Jaguars in this match with a solid defense up in their sleeve. Look for the San Francisco 49ers to win on the road with a predicted score of 31-13.


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San Francisco 49ers vs Jacksonville Jaguars 11/21/2021 Picks Predictions Previews

NFL Starting Time: 1:00 PM ET 


Location: Tiaa Bank Field  


Date: Sunday, November 21, 2021




NFL Odds: San Francisco 49ers -6.5


NFL Totals: 45


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