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San Francisco 49ers vs Philadelphia Eagles 9/19/2021 Picks Predictions Previews

San Francisco 49ers vs Philadelphia Eagles 9/19/2021 Picks Predictions Previews


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The San Francisco 49ers will go against the Philadelphia Eagles in NFL action in Lincoln Financial Field, on Sunday, September 19, 2021, at 1:00 PM ET. The Niners defeated the Lions by an eight-point margin. In week one against the Lions, San Francisco had a massive halftime advantage but still needed to finish aggressively to prevail. The 49ers led 31-10 at halftime but were given a fright in the fourth quarter when Detroit scored 16 points in a 41-33 49ers victory.


On 17-of-25 passing in week one, Jimmy Garoppolo, the 49ers quarterback, threw for 314 yards and one touchdown. Eli Mitchell rushed for 104 yards and a touchdown on 19 carries, and Deebo Samuel caught nine passes for 189 yards and a touchdown.


  • The San Francisco 49ers are 3-7 ATS in their last 10 matches.
  • The San Francisco 49ers are 1-8 ATS in their last 9 matches against Philadelphia.
  • The San Francisco 49ers are 13-5 SU in their last 18 matches on the road.

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San Francisco 49ers vs Philadelphia Eagles Predictions 9/19/2021


For the Eagles, their first match was against the Falcons. In that encounter, Philly won by a score of 26 points. The Eagles led the Falcons 15-6 at halftime in Week 1 of the regular season. Philadelphia, on the other hand, took command of the game after that, going on a 17-0 run to start the season with a 32-6 win.


Jalen Hurts, the Eagles’ quarterback, threw for 264 yards and three touchdowns on 27-of-35 passing. Miles Sanders rushed for 74 yards on 15 rushes, while DeVonta Smith topped the receiving corps with 6 receptions for 71 yards and a touchdown.


  • The Philadelphia Eagles are 2-7 SU in their last 9 matches.
  • The Philadelphia Eagles are 4-8 SU in their last 12 matches when competing at home against San Francisco.
  • The Philadelphia Eagles are 5-1 ATS in their last 6 matches at home.

San Francisco 49ers vs Philadelphia Eagles. The NFL pick for this game is the Philadelphia Eagles. In this one, I prefer the Eagles. Philadelphia’s offense was well-balanced in week one, with 261 passing yards and 173 rushing yards for a 6.5 yards-per-play average. The Eagles, on the other hand, will have to clean up their penalties (14 for 89 yards). The 49ers, on the other hand, were rolling along on offense, averaging 8.0 yards per carry. San Francisco only fumbled the ball twice and allowed one sack despite losing a few turnovers. Nevertheless, this should be an entertaining and challenging match, and I prefer the Eagles on the cover. The Philadelphia Eagles will win to a predicted score of 27-24.


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San Francisco 49ers vs Philadelphia Eagles 9/19/2021 Picks Predictions Previews

NFL Starting Time: 1:00 PM (EDT)


Location: Lincoln Financial Field, USA


Date: Sunday, September 19, 2021




NFL Odds/Point Spread: Philadelphia Eagles +3.5


NFL Totals: 50


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