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San Francisco 49ers vs. Minnesota Vikings NFL Betting Pick Prediction 10/23/2023
49ers at Vikings—San Francisco receiver Deebo Samuel is out, and their left tackle is doubtful. Running back Christian McCaffrey is questionable. On defense a linebacker is questionable. Minnesota receiver Justin Jefferson is out and the left guard questionable. A cornerback is questionable on defense. San Francisco fell to 5-1 with their 19-17 road defeat to the Cleveland Browns. The 49ers rushed for 108 yards on 25 carries. They surrendered 160 yards rushing to the Browns with 174 passing on 34 attempts. Brock Purdy completed 12 of 27 for 125 yards with a touchdown and interception. He averaged 4.6 yards per pass attempt, a season low. Minnesota improved to 2-4 after their 19-13 road win against the Chicago Bears. The Vikings rushed for 46 yards on 22 carries. They surrendered 162 yards rushing to the Bears with 113 passing on 24 attempts. Minnesota had a +2-turnover margin. Kirk Cousins hit 21 of 31 passes for 181 yards with a touchdown. He averaged a season low of 5.8 yards per pass attempt. Cousins has not been efficient the past two games. The Vikings will miss Jefferson here in this spot. McCaffrey is trending toward playing but a key receiver option out for the 49ers. San Francisco has the third rated defense in the NFL by allowing only 278 yards per game. Vikings one dimensional with lose rushing attempts which is concerning based on their inefficiency passing the past two weeks. Vikings defend the run well and the 49ers rank second in the number of rushes per game. Play San Francisco and Minnesota under 43.