Kansas City Chiefs vs Indianapolis Colts 9-25-22

Kansas City Chiefs vs Indianapolis Colts 9/25/2022 Picks Predictions Previews

Kansas City Chiefs vs Indianapolis Colts 9/25/2022 Picks Predictions Previews


The Kansas City Chiefs will go against the Indianapolis Colts in NFL action in Lucas Oil Stadium, IN, on Sunday, September 25, 2022, at 1:00 PM ET.


Kansas City is now 2-0 and just defeated the Chargers in a hard-fought victory. In their first game of the 2022 season, Kansas City defeated the Cardinals 44–21 while scoring in each of the game’s four quarters.


Isiah Pacheco led the run with 62 yards and a touchdown, while quarterback Patrick Mahomes passed for 360 yards and 5 touchdowns.


The Chiefs played much more closely in game two, but the result remained the same. Kansas City defeated the Chargers 27-24 by scoring 13 points in the fourth quarter.


In that game, Mahomes completed 24 of 35 passes for 235 yards and two touchdowns.


  • The Kansas City Chiefs are 9-4 ATS in their last 13 matches.
  • The total went OVER in 8 of Kansas City’s last 10 games.
  • The Kansas City Chiefs are 13-2 SU in their last 15 matches.

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Kansas City Chiefs vs Indianapolis Colts Predictions 9/25/2022


The Colts have a 0-1-1 record so far this season after losing to the Jaguars in their most recent match. On the Colts’ side, a wild contest versus the Texans opened the new season.


After falling down 20-3 in the fourth quarter, Indianapolis rallied to tie the game.


Matt Ryan, the quarterback, completed 32 of 50 passes for 352 yards, one touchdown, and one interception. The Colts’ second game did not go well. They faced the Jaguars, a team in their division, and lost badly, 24-0, behind at the half by a score of 17-0.


Jonathan Taylor led the rush with 54 yards on nine attempts, while Ryan finished the game with 195 passing yards and three interceptions.


  • The Indianapolis Colts are 1-4 ATS in their last 5 matches. 
  • The total went UNDER in 7 of Indianapolis’ last 7 games. 
  • The total went UNDER in 5 of the Colts’ last 6 matches against Kansas City.

Kansas City Chiefs vs Indianapolis Colts. The NFL pick for this game is the Kansas City Chiefs. Kansas City’s victory against the Los Angeles Chargers was lucky since it allowed LA to gain 401 total yards, 5.4 yards per play, and 21 first downs.


Even though they only generated 15 first downs and had a dismal 4-of-12 third-down attempt, the Chiefs managed to win the match. The offense might need some work, but it was not too horrible.


After that humiliating shutout defeat to the Jacksonville Jaguars, the Colts have a lot of work to do. Only 218 total yards, nine first downs, and a 2-of-10 run on third downs were created by Indianapolis.


The KC Chiefs will likely have to take the cover here even though the Colts will look superior. The Kansas City Chiefs will win to a predicted score of 28-24.


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Kansas City Chiefs vs Indianapolis Colts 9/25/2022 Picks Predictions Previews

NFL Starting Time: 1:00 PM (EDT)


Location: Lucas Oil Stadium, IN


Date: Sunday, September 25, 2022




NFL Odds: Kansas City Chiefs -6.5


NFL Totals: 49.5


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