Kansas City Chiefs vs San Francisco 49ers 10-23-22

Kansas City Chiefs vs San Francisco 49ers 10/23/2022 Picks Predictions Previews

Kansas City Chiefs vs San Francisco 49ers 10/23/2022 Picks Predictions Previews


The Kansas City Chiefs will go against the San Francisco 49ers in NFL action in Levi’s Stadium, San Francisco, CA, on Sunday, October 23, 2022, at 4:25 PM ET.


The Kansas City Chiefs enter the game with a 4-2 record so far this year. The Chiefs lost their most recent game, which they played against the Bills, 24-20.


The Chiefs’ top rusher, Clyde Edwards-Helaire, with 9 attempts for 33 yards (3.7 yds per carry). JuJu Smith-Schuster finished with 113 yards on 5 catches, averaging 22.6 yards per catch.


The performance of Patrick Mahomes was 25/40 for 338 yards and 2 touchdowns in the air. He finished the game with 2 interceptions and an 85.2 QB rating.


The Chiefs gave up 125 yards on 31 attempts, or an average of 4.0 yards per rush, against the run. For a completion rate of 67.5%, Kansas City allowed 27 pass completions on 40 attempts for 318 yards.


After everything was said and done, they had 61 plays totaling 387 yards. The Chiefs carried the ball 18 times for a total of 68 yards, or an average of 3.8 yards per carry.


  • The Kansas City Royals are 1-4 ATS in their last 5 matches. 
  • The total went OVER in 10 of Kansas City’s previous 14 outings. 
  • The Royals are 15-4 SU in their last 19 matches.

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Kansas City Chiefs vs San Francisco 49ers Predictions 10/23/2022


The 49ers enter the game with a 3-3 record thus far this season. The 49ers were trounced 28-14 by the Falcons when they last played on a football field, sending them home.


For San Francisco, Jeff Wilson carried the rock seven times for a distance of 25 yards, averaging 3.6 yards per carry. The 49ers’ passing game included Brandon Aiyuk, who caught 8 receptions for 83 yards (10.4 yards per catch).


Jimmy Garoppolo (2 touchdowns) completed 29 of his 41 passes for 296 yards, good for an 87 quarterback rating, as the game came to a close. He threw two interceptions and averaged 7.2 yards per attempt.


San Francisco gave up 168 yards on 40 rushing attempts (4.2 yds per rush). The 49ers’ secondary gave up 121 yards on 13 of 14 passes, allowing a 92.9% completion rate.


  • The San Francisco 49ers are 8-3 ATS in their last 11 matches. 
  • The total went UNDER in 8 of San Francisco’s previous 9 contests. 
  • The 49ers are 12-6 SU in their last 18 matches.

Kansas City Chiefs vs San Francisco 49ers. The NFL pick for this game is the Kansas City Chiefs. Following a heartbreaking defeat to the Buffalo Bills, the Kansas City Chiefs will try to rebound with a good performance on the road Sunday.


The Chiefs will have the advantage on offense as they are averaging 29.8 points per game, which is the best in the NFL, while San Francisco only posts an average of 20.3 points per game.


Kansas City covered the number in five of the previous six games with San Francisco. The Kansas City Chiefs will win to a predicted score of 27-20.


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Kansas City Chiefs vs San Francisco 49ers 10/23/2022 Picks Predictions Previews

NFL Starting Time: 4:05 PM (EDT)


Location: Levi’s Stadium, San Francisco, CA


Date: Sunday, October 23, 2022




NFL Odds: San Francisco 49ers +2.5


NFL Totals: 48.5


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