Pittsburgh Pirates vs Chicago Cubs 4-21-22

Pittsburgh Pirates vs Chicago Cubs 4/21/2022 Picks Predictions Previews

Pittsburgh Pirates vs Chicago Cubs 4/21/2022 Picks Predictions Previews


The Pittsburgh Pirates will face off against the Chicago Cubs in Game 1 of a four-game series at Wrigley Field, Chicago, IL, on Thursday, April 21, 2022, at 7:40 PM EDT.


The Pirates are entering this match after wrapping up a 3-game series versus the Milwaukee Brewers. Pittsburgh were swept by the Brewers at Milwaukee, pushing the Pirates’ to a measly 1-5 road record on the year and the team is 0-7 this season when scoring 3 or fewer runs.


Leading Pittsburgh is Ke’Bryan Hayes with 14 hits and 4 RBIs followed by Daniel Vogelbach and Michael Chavis who combined for 22 hits and 9 RBIs. 


For Thursday’s game, the Pirates are expected to send Bryse Wilson to the mound. He is 0-0 with an ERA of 5.40 ERA 8.1 innings this season. Wilson may not have been the sharpest on the year but he has not lost any ball games for Pittsburgh in his two outings so far.


The right-hander only has 4 KS and has conceded 2 homers, 4 BBs, and 9 base hits in the 8.1 innings of work this season. 


  • The Pittsburgh Pirates are 2-10 SU in their last 12 games against the Chi Cubs.
  • The Pirates are 1-6 SU in their last 7 games down the road.
  • The total went OVER in 5 of Pittsburgh’s last 5 games when playing on the road against the Chi Cubs.

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Pittsburgh Pirates vs Chicago Cubs Predictions 4/21/2022


The Chicago Cubs are coming to this game after losing to the Tampa Bay Rays in a game that was called after only six innings due to weather. Tampa Bay won by a score of 8-2 and Chicago is now back to .500 at 6-6 after losing two straight at home against the Rays.


The Cubs are 5-4 this season when scoring 4 or more runs. Leading Chicago is Ian Happ with 12 hits and 6 RBIs followed by Frank Schwindel and Seiya Suzuki who have combined for 24 hits and 18 RBIs. 


For Game 1, Mark Leiter Jr. will head to the hill for the Cubs. Leiter Jr. had a rough season debut as he was rocked by the Colorado Rockies at Coors Field after he allowed a home run, 4 BBs, 5 hits, and 7 earned runs in only 3.1 innings of work. The right-hander is 0-1 with an ERA 3.00 and 8 KS in his career against the Pirates.


  • The total went OVER in 7 of the Chi Cubs’ last 10 games against the Pirates.
  • The Chi Cubs are 3-12 SU in their last 15 games at home.
  • The total went OVER in 5 of the Chi Cubs’ last 5 games at home against Pittsburgh.

Pittsburgh Pirates vs Chicago Cubs. The MLB pick for this contest is the Chicago Cubs. The Pirates’ Bryse Wilson has not been very good in his first two starts and the team itself has been terrible on the defensive side of the field as of late.


Meanwhile, the Cubs have been a lot cleaner in the field and are the overall better offensive team. Prediction: The Chicago Cubs win this match to a score of 4-3.


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Pittsburgh Pirates vs Chicago Cubs 4/21/2022 Picks Predictions Previews

MLB Starting Time: 7:40 PM (EDT)


Location: Wrigley Field, Chicago, IL


Date: Thursday, April 21, 2022




MLB Odds: Chicago Cubs -145


MLB Totals: 6.5


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