Chicago White Sox vs Cleveland Guardians 4-21-22

Chicago White Sox vs Cleveland Guardians 4/21/2022 Picks Predictions Previews

Chicago White Sox vs Cleveland Guardians 4/21/2022 Picks Predictions Previews


The Chicago White Sox will meet with the Cleveland Guardians in MLB action in Progressive Field, OH, on Thursday, April 21, 2022, at 1:10 PM (EDT). Before having two matches at home washed out in Cleveland, Chicago captured two of three at home versus Tampa Bay.


The White Sox entered Wednesday with a 6-3 record, two matches ahead of the Royals and Guardians in the AL Central. Chicago had only 3 hits in their last game against Tampa Bay on Sunday and went 0 for 5 with runners in scoring position.


The Pale Hose’s Gavin Sheets (run, two RBI) smashed his first home run of the year in the ninth inning, but it wasn’t enough to win the game.


On the mound, Vince Velasquez (0-1) came up short after allowing four runs (three earned) on five hits in 4.2 innings with 3 walks and 5 strikeouts. In the competition, he also made two faults.


Dylan Cease takes the mound for the White Sox, making his third appearance of the 2022 season. He enters the game with a 2-0 record, a 1.69 ERA, a 0.938 WHIP, 5 walks, and 16 strikeouts in 10.2 innings pitched. Cease won his last start, which he made against the Rays at home on Friday.


In a 3-2 White Sox victory, he pitched 5.2 innings, giving one run on 3 hits with 2 walks and eight strikeouts. In this game, Cease makes his sixth career appearance versus the Guardians.


  • The total went UNDER in 4 of Chi White Sox’s last 6 matches.
  • The White Sox are 2-4 SU in their previous 6 matches.
  • Chicago is 2-5 SU in their last 7 matches on the road.

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Chicago White Sox vs Cleveland Guardians Predictions 4/21/2022


Cleveland, like the White Sox, benefited from the rainouts in terms of allowing their pitchers to rest. The Guardians were tied for second place in the AL Central on Wednesday, two matches behind the White Sox for the division lead.


The Guardians failed to put runs on the board in the last game of the series against San Francisco, finishing with only six hits. No player had more than one hit in the game, with Cleveland’s Austin Hedges driving in the game’s lone run in the seventh inning.


The Guardians were one of eight teams in the competition with runners in scoring position. On the mound, Aaron Civale (0-1) came up short, pitching four innings and surrendering four runs (three earned) on 4 hits with one walk and 5 strikeouts.


In this game, Zach Plesac will make his third appearance of the season for the Guardians. Plesac’s previous start was against the Giants at home on Friday, and he came up short.


In a 4-1 loss against the Guardians, he pitched 5.1 innings, giving two runs on 7 hits with one walk and four strikeouts. In this game, Plesac makes his 10th career appearance against the White Sox.


  • The total went OVER in 6 of Cleveland’s last 9 matches.
  • The Cleveland Guardians are 6-3 SU in their previous 9 matches.
  • The total went UNDER in 4 of Cleveland’s last 5 matches against the Chi White Sox.

Chicago White Sox vs Cleveland Guardians. The MLB pick for this game is the Cleveland Guardians. In the first game of the doubleheader on Wednesday afternoon, the Guardians attacked like Cobra Kai, striking fast and hard while showing no compassion.


Cleveland pounded Keuchel to the tune of 10-0 before recording an out in the second inning on their way to an 11-1 victory. Cease performed effectively so far this year, but the White Sox will be dealing with a lean bullpen following the work they had to do on Wednesday.


After a sluggish start, Cleveland put up a great offensive showing in the opening, and they awakened a little offensively. Plesac pitches well at home and given Cease’s problems at Progressive Field, the hosts have to win this one. The Cleveland Guardians will win to a predicted score of 5-4.


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Chicago White Sox vs Cleveland Guardians 4/21/2022 Picks Predictions Previews

MLB Starting Time: 1:10 PM (EDT)


Location: Progressive Field, OH


Date: Thursday, April 21, 2022




MLB Odds: Chicago White Sox -145


MLB Totals: 8


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