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Carolina Panthers vs Buffalo Bills 12/19/2021 Picks Predictions Previews

Carolina Panthers vs Buffalo Bills 12/19/2021 Picks Predictions Previews


The Carolina Panthers will collide with the Buffalo Bills at Highmark Stadium in Orchard Park, NY on Sunday afternoon. The Panthers are on a 3-game losing slump after bowing out to the visiting Atlanta Falcons to a score of 21-29 at Bank of America Stadium in Charlotte, North Carolina this past Sunday.


Carolina’s hope for a playoff berth faded after losing 3 games in a row, the recent one to the Falcons. The Carolina Panthers are the cellar dwellers at 5-8 in the American Football Conference South Division. 


In The Panthers’ loss to the Falcons last week, QB Cam Newton completed 15 of 23 passes for 178 yards and one interception. P.J. Walker completed six of 12 for 75 yards with one TD and one pick.


Carolina managed 334 yards of total offense but had 3 turnovers including a 66-yard pick-six by the Falcons in the second quarter. Starting QB Cam Newton was benched in the second half but will start on Sunday.


  • The Carolina Panthers are 2-5 SU in their last 7 games against the Buffalo Bills.
  • Carolina is 10-3 ATS in their last 13 games down the road.
  • The Panthers are 1-4 ATS in their last 5 games this season.

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Carolina Panthers vs Buffalo Bills Predictions 12/19/2021


The Buffalo Bills are struggling with their defenses as they met QB Tom Brady and the Bucs and lost to a score of 27-33 at Hard Rock Stadium in Tampa, Florida, Sunday. The Bills missed the defending skills of Tre’Davious White. Buffalo dropped to 7-6 following their recent loss and is currently second in the AFC East two games behind first-place New England. 


The Bills have lost two straight and three of the last four. Buffalo gained 466 yards of total offense but allowed Tampa Bay 488 yards of total offense. Buffalo rallied with two touchdowns and a field goal in the fourth quarter to send the game to overtime but lost in the extra period.


QB Josh Allen passed 3,524 yards with 28 TDs and 11 interceptions. RB Devin Singletary rushed for 547 yards and two touchdowns while the leading receiver is Stefon Diggs with 972 yards and seven TD receptions. On defense, Tremaine Edmunds is the leading tackler with 82 and Mario Addison is the leader in sacks with 4.0.


  • The Buffalo Bills are 10-3 SU in their last 13 games at home.
  • Buffalo is 8-1 ATS in their last 9 games against an opponent in the NFC.
  • The Bills are 6-12 SU in their last 18 games against an opponent in the NFC South.

Carolina Panthers vs Buffalo Bills. The NFL pick for this game is the Buffalo Bills. Buffalo will bounce back with a home win over the Panthers in this contest, but the play will be enough to cover the number.


The visiting team (CAR) covered the number in four of the last five played between the two. The Panthers are holding opponents at 21.7 points per game which is the eighth-best in the NFL. Final Score Prediction, Buffalo Bills win but fall short ATS 27-20.


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Carolina Panthers vs Buffalo Bills 12/19/2021 Picks Predictions Previews

NFL Starting Time: 1:00 PM (EDT)


Location: Highmark Stadium in Orchard Park, NY


Date: Sunday, December 19, 2021




NFL Odds/Point Spread: Buffalo Bills -10.5


NFL Totals: 43.5 


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