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Indianapolis Colts vs Buffalo Bills 11/21/2021 Picks Predictions Previews

Indianapolis Colts vs Buffalo Bills 11/21/2021 Picks Predictions Previews


The Indianapolis Colts will face off with the Bills on Sunday at Highmark Stadium in Orchard Park, New York. Indiana disposed of 2 weaker teams in its last 2 meetings.


The Colts recently trounced the visiting Jacksonville Jaguars to a score of 23-17 at Lucas Oil Stadium in Indianapolis, Sunday. Indianapolis gained 295 yards of total offense while holding Jacksonville to 331 yards of total offense. The Colts are 2nd at 5-5 in the AFC South.


QB Carson Wentz threw 2,378 yards, 17 TDs, and 3 interceptions on 63.5% passing while RB Jonathan Taylor leads the ground assault with 937 rushing yards and 9 TDs.


WR Michael Pittman Jr. leads the Colts with 55 catches for 729 yards and 5 scores, Zach Pascal has 328 receiving yards with 3 scores, and Mo Alie-Cox has 4 touchdown grabs with 211 receiving yards this season. On defense, Bobby Okekreke leads the Colts with 86 total tackles while DeForest Buckner has a team-high 4.5 sacks.


  • The Indianapolis Colts are 8-4 SU in their last 12 games against the Bills.
  • The total went OVER in 6 of Indianapolis’ last 7 games down the road.
  • Indianapolis is 1-4 SU in their last 5 games when playing on the road against Buffalo.

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Indianapolis Colts vs Buffalo Bills Predictions 11/21/2021


At “The Big Apple”, the Buffalo Bills are back home after routing the Jets to a score of 45-17 at MetLife Stadium in East Rutherford, NJ,  Sunday.


The Bills have the defensive units feared by opponents in the league. Buffalo will take the opportunity to build its momentum over the Jets in their recent road win. The Buffalo Bills are on top at 6-3 in the AFC East.


QB Josh Allen threw 366 yards with a pair of touchdowns and one interception. The Bills’ defense held the Jets to 366 yards of total offense and forced five Jets’ turnovers.


Buffalo did not allow New York to score a TD until the fourth frame when the Bills led 38-3. Matt Breida, Devin Singletary, and Zack Moss make up for the Bill’s tough defense. 


  • The total went UNDER in 4 of Buffalo’s last 5 games against the Indianapolis Colts.
  • The Buffalo Bills are 10-1 SU in their last 11 games at home.
  • Buffalo is 4-1 SU in their last 5 games when playing at home against Indianapolis.

Indianapolis Colts vs Buffalo Bills. The NFL pick for this contest is the Buffalo Bills. The Colts can take advantage of their healthy offensive lineup over the Bills. Indianapolis sees their opening in the AFC South race and needs to keep putting forth solid performances.


Bills QB Josh Allen is feeling the rush after crashing the Jets. The Buffalo Bills will win at home but will fall short against the spread predicted to a score of 27-24


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Indianapolis Colts vs Buffalo Bills 11/21/2021 Picks Predictions Previews

NFL Starting Time: 1:00 PM EDT


Location: Highmark Stadium in Orchard Park, NY


Date: Sunday, November 21, 2021




NFL Odds/Point Spread: Buffalo Bills -7.5


NFL Totals:  49.5


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