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Los Angeles Rams vs San Francisco 49ers 11/15/2021 Picks Predictions Previews

Los Angeles Rams vs San Francisco 49ers 11/15/2021 Picks Predictions Previews


The Los Angeles Rams will step into Levi’s Stadium to face off with the 49ers in San Francisco on Monday evening. The Rams recently lost to the visiting Tennessee Titans to a score of 16-28 at SoFi Stadium in Inglewood, CA last Sunday.


Los Angeles lost its last 4 outings against the 49ers. The LA Rams are 2nd at 8-1 in the NFC West Division.


Last Sunday’s match went awry for the Rams as Matthew Stafford capped his game with 294 passing yards and a touchdown, but not before throwing two first-half picks that converted into Tennessee touchdowns and an early 14-3 rut.


It was just an all-around off-night for a Rams team that has had very few of them across this impressive 7-2 SU campaign. RB Darrell Henderson JR. has a team-high 562 rushing yards and 5 TDs this season.


  • The LA Rams are 3-8 ATS in their last 11 matches against the 49ers.
  • The Los Angeles Rams are 1-4 SU in their last 5 games against San Francisco.
  • The Rams are 5-1 SU in their last 6 games down the road.

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Los Angeles Rams vs San Francisco 49ers Predictions 11/15/2021


In the Bay Area, The San Francisco 49ers are back to the losing column after snapping out of their 4-game losing skid via a victory over the Chicago Bills.


The 49ers recently lost to the visiting Arizona Cardinals to a score of 17-31 last Sunday. QB Jimmy Garoppolo threw 1,754 yards, 8 touchdowns, and 5 interceptions on 65.3% passing on the season. San Francisco is last at 3-5 in the NFC West Division. 


RB Elijah Mitchell leads the 49ers with 469 rushing yards and 3 scores. WR Deebo Samuel leads San Fran’s receiving group with 49 grabs for 882 yards and 4 TDs while WR George Kittle has 328 receiving yards and Brandon Aiyuk has 230 receiving yards.


Mohamed Sanu and Kyle Juszczyk each have 100+ receiving yards as well this season. On defense, Fred Warner leads the Niners with 75 total tackles while Nick Bosa has a team-high 7 sacks this season. 


  • The total went UNDER in 4 of San Francisco’s last 6 games against the LA Rams.
  • The San Francisco 49ers are 0-8 SU in their last 8 games at home.
  • The total went UNDER in 6 of San Francisco’s last 8 games at home with the LA Rams.

Los Angeles Rams vs San Francisco 49ers. The NFL Pick for this game is the Los Angeles Rams. The Niners were awful and that’s not acceptable in a division game in primetime.


The Rams are 12-3-1 ATS in their last 16 games following a straight-up loss. Take the Rams to win this match predicted at 27-24.


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Los Angeles Rams vs San Francisco 49ers 11/15/2021 Picks Predictions Previews

NFL Starting Time: 8:15 PM ET


Location: Levi’s Stadium in San Francisco, CA


Date: Monday, November 15, 2021




NFL Odds/Point Spread: Los Angeles Rams -3.5


NFL Odds Total: 50.5


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