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Clemson Tigers vs Louisville Cardinals 11/6/2021 Picks Predictions Previews

Clemson Tigers vs Louisville Cardinals 11/6/2021 Picks Predictions Previews


The Clemson Tigers will go against the Louisville Cardinals in NCAAF action in Cardinal Stadium, Louisville, KY, on Saturday, November 6, 2021, at 1:00 PM (EDT).


After a 30-20 win over the Florida State Seminoles on Saturday, Clemson climbed to 5-3 overall and 4-2 in the ACC. D.J. Uiagalelei of Clemson threw for 189 yards, 1 touchdown, and one interception, while Will Shipley of Clemson ran for 128 yards and two scores. Clemson limited Florida State to 241 total yards.


QB D.J. Uiagalelei has 1,291 passing yards, 5 touchdowns, and 6 interceptions, while Will Shipley has 391 rushing yards and 7 scores for Clemson. Justyn Ross leads the team in receiving yards with 426 and three touchdowns.


On defense, linebacker James Skalski leads the team with 70 tackles, while defensive end Myles Murphy leads the team with 5.5 QB sacks.


  • Clemson University Tigers is 1-8 ATS in their last 9 games.
  • The Tigers are 4-1 ATS in their last 5 matches against Louisville Cardinals.
  • Clemson is 15-3 SU in their last 18 away matches.

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Clemson Tigers vs Louisville Cardinals Predictions 11/6/2021


After a 28-13 defeat against the North Carolina State Wolfpack on Saturday, Louisville is now 4-4 overall and 2-3 in the ACC. The total offense for Louisville was 434 yards.


After leading 10-7 approaching the fourth quarter, Louisville was outscored 21-3 in the final stanza. Malik Cunningham, the team’s quarterback, threw for 219 yards, one touchdown, and one interception while also rushing for 76 yards.


Malik Cunningham leads the team in passing with 1903 yards, 9 touchdowns, and 5 interceptions. He also leads the team in rushing with 556 yards and 13 touchdowns. Jordan Watkins leads the team in receiving yards with 375 and two touchdowns.


On defense, linebacker CJ Avery leads the team with 53 tackles and linebacker Yashir Abdullah leads the team with 6.0 QB sacks.


  • The Louisville Cardinals are 4-2 ATS in their last 6 matches.
  • The total went UNDER in 4 of Louisville’s last 5 matches.
  • The Cardinals are 5-1 SU in their last 6 home matches.

Clemson Tigers vs Louisville Cardinals. The NCAAF pick for this game is the Clemson Tigers. On Saturday, Clemson will overcome Louisville, but the UNDER is the play. Six of Clemson’s past eight games went UNDER, while four of Louisville’s last five went UNDER.


Clemson boasts one of the finest defenses in the country, permitting only 15.3 points per game on average. Clemson’s offense, on the other hand, isn’t very good, with the Tigers averaging only 21.3 points per game. With Clemson dominating and the UNDER paying, expect a low-scoring fight. The Clemson Tigers will win to a predicted best play of UNDER 24-20.


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Clemson Tigers vs Louisville Cardinals 11/6/2021 Picks Predictions Previews

NCAAF Starting Time: 1:00 PM (EDT)

Location: Cardinal Stadium, Louisville, KY, USA

Date: Saturday, November 6, 2021


NCAAF Odds: Clemson Tigers -3.5

NCAAF Totals: 45


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