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Arizona Cardinals vs San Francisco 49ers 11/6/2021 Picks Predictions Previews

Arizona Cardinals vs San Francisco 49ers 11/6/2021 Picks Predictions Previews


The Arizona Cardinals will step into Levi’s Stadium in Santa Clara for an inter-division showdown with the 49ers in San Francisco on Sunday afternoon. The Cardinals had a 7-game winning run until the visiting Green Bay Packers dislodged the fortified team to a score of 21-24 at State Farm Stadium in Glendale, Arizona last Thursday.


QB Kyler Murray sprained his left ankle in the lost game to the Packers and will be good to go in this match. Arizona leads at 7-1 in the National Football Conference West Division.


The Cardinals will look to bounce back from their loss to the Packers in their first defeat of the season. Murray threw 2,276 yards, 17 TDs, and 7 picks on 72.7% passing while RB Chase Edmonds rushed for 427 yards while RB James Conner had 358 rushing yards with 8 TDs this season.


WR DeAndre Hopkins has a team-high 35 catches for 486 yards and 7 TDs while A.J. Green and Christian Kirk each dashed for 450+ receiving yards. WR Rondale Moore has 327 receiving yards.


  • The Arizona Cardinals are 6-1-1 ATS in their last 8 matches against the 49ers.
  • Arizona is 10-3 SU in their last 13 games against San Francisco.
  • The Cardinals are 5-1 ATS in their last 6 games down the road.

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Arizona Cardinals vs San Francisco 49ers Predictions 11/6/2021


AT ”The Bay Area”, the San Francisco 49ers crawled out from their rut after beating the Bears to a score of 33-22 at Soldier Field in Chicago last Sunday. The 49ers are on a 7-game losing streak at home and hope to end that trend with a victory in this contest. San Francisco is 3rd at 3-4 in the National Football Conference West Division.


QB Jimmy Garoppolo silenced some of his critics in his homecoming victory to Chicago last Sunday, throwing for 322 yards and running for two touchdowns to keep the 49ers’ season afloat. However, the 49ers must win more matches to get at the level where the Cardinals and the Rams are.


WR Deebo Samuel leads with 44 grabs for 819 yards and 4 TDs while George Kittle’s posted 227 receiving yards and another three 49ers have at least 100 receiving yards as well this season.


  • The total went UNDER in 7 of San Francisco’s last 10 matches with the Cardinals.
  • San Francisco is 0-7 SU in their last 7 games at home.
  • The 49ers are 1-5 SU in their last 6 games when playing at home against Arizona.

Arizona Cardinals vs San Francisco 49ers. The NFL Pick for this contest is the Arizona Cardinals. Arizona has a solid offense which the 49ers will find hard to contain. San Francisco also has a dynamic offense but is unlikely to penetrate the Cardinals’ defenses.


Garoppolo gained some much-needed confidence against the Bears, and he needs to carry that with him and play the same way in front of his home fans now. Likewise, pressuring Murray and forcing him into some more turnovers could lead to a SU upset. Prediction: The Cardinals win this round UNDER 24-21.


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Arizona Cardinals vs San Francisco 49ers 11/6/2021 Picks Predictions Previews

NFL Starting Time: 4:25 PM ET


Location: Levi’s Stadium in Santa Clara, San Francisco, CA


Date: Sunday, November 7, 2021




NFL Odds/Point Spread: Even


NFL Totals: 46.5


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