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San Francisco 49ers vs Arizona Cardinals 10/10/2021 Picks Predictions Previews

San Francisco 49ers vs Arizona Cardinals 10/10/2021 Picks Predictions Previews


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The San Francisco 49ers will meet with the Arizona Cardinals in NFL action in State Farm Stadium, Glendale, on Sunday, October 10, 2021, at 4:25 PM (EDT). The San Francisco 49ers need to earn this match to move above .500. The San Francisco 49ers captured three matches in a row on the road. Jimmy Garoppolo threw for 925 yards, five touchdowns, and 2 interceptions on 66.1 percent of his throws. Kyle Juszczyk has 11 catches, while George Kittle and Deebo Samuel collaborated for 717 receiving yards and 3 touchdowns.


The running game for the San Francisco 49ers is generating 120.2 yards per game, with Elijah Mitchell leading the way with 146 yards and a score. San Francisco is surrendering 24.3 points and 316.7 yards per game on defense. With 36 tackles, Nick Bosa owns four sacks, and Dre Greenlaw has one interception, the San Francisco 49ers are in first place.


  • The San Francisco 49ers are 4-9 ATS in their last 13 matches.
  • The 49ers are 1-5-1 ATS in their last 7 matches against Arizona.
  • San Francisco is 4-1 SU in their last 5 matches on the road.

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San Francisco 49ers vs Arizona Cardinals Predictions 10/10/2021


The Arizona Cardinals have a 2-2 record in their last eight matches at home. Kyler Murray threw for 1,273 yards, 9 touchdowns, and four interceptions on 76.1 percent of his throws. DeAndre Hopkins boasts 17 catches, while Christian Kirk and  AJ Green collaborated for 492 receiving yards and four touchdowns.


Chase Edmonds boasts 255 yards on 43 runs to lead the Arizona Cardinals’ ground attack, which is generating 147.8 yards per game. Arizona allows 23.5 points and 350 yards per game on defense. Isaiah Simmons has 23 tackles, Chandler Jones gets five sacks, and Byron Murphy Jr. has two interceptions for the Arizona Cardinals.


  • The total went UNDER in 4 of Arizona’s last 6 matches.
  • The total went UNDER in 6 of Arizona’s last 9 matches against San Francisco.
  • The total went OVER in 6 of Arizona’s last 7 matches at home.

San Francisco 49ers vs Arizona Cardinals. The NFL pick for this game is the Arizona Cardinals. The San Francisco 49ers gained two matches on the road this season, but they had a difficult stretch of games recently, are bruised up, and their defense showed symptoms of fading, as they’re now ranked 22nd in scoring defense. The Arizona Cardinals finally have a home match after playing three of their first four games on the road, and they’re on fire offensively. The Cardinals lead the league in both overall and scoring offense. The line isn’t cheap, but the 49ers appear to be in a tough situation. I’m going with the Cardinals by a touchdown. The Arizona Cardinals will win to a predicted score of


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San Francisco 49ers vs Arizona Cardinals 10/10/2021 Picks Predictions Previews

NFL Starting Time: 4:25 PM (EDT)


Location: State Farm Stadium, Glendale, USA


Date: Sunday, October 10, 2021




NFL Odds/Point Spread: Arizona Cardinals -2.5


NFL Totals: 45.5


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