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Minnesota Twins vs Chicago Cubs 9/22/2021 Picks Predictions Previews

Minnesota Twins vs Chicago Cubs 9/22/2021 Picks Predictions Previews


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The Wrigley Field will play host to the second game between the Minnesota Twins and the Chicago Cubs on Wednesday night.  On Tuesday, Minnesota defeated the Cubs by 4 runs.  The Twins are in last place at the AL Central Division at  66-85 while the Cubs are in fourth-place at the NL Central Division at 67-84. 


The Minnesota Twins put in an explosive effort to defeat the Cubs on Tuesday.  Nick Gordon hit a two-run homer and two singles, Josh Donaldson and Max Kepler each had three hits and two RBIs.  Mitch Garver had three singles and Byron Buxton had two hits and scored twice and the Twins won 9-5 against the Cubs.  The win snapped a two-game losing streak.  Minnesota dropped to 19th in batting with an average of .239 and dropped 16th with 670 runs scored and ranks 18th in on-base percentage at .312.  The Twins struggled at the mound posting a team ERA of 4.89, 27th in the league, and a WHIP of 1.32, 18th in the league.  They allow the opponents to bat at an average of .256 which is 24th in the league.  Joe Ryan gets the ball for the Twins in Wednesday’s game.  The right-hander is 1-1 with a 2.12 ERA.  Through 17.0 innings of work, Ryan has 7 hits, 4 earned runs, allowed 2 homers, 2 walks, and 13 strikeouts.  


  • The Minnesota Twins are 3-8 SU in its last 11 games against the Chicago Cubs.
  • The total went OVER in 5 of Minnesota’s last 7 games on the road against the Chicago Cubs.
  • The total went UNDER in 6 of Minnesota’s last 9 games on the road.

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Minnesota Twins vs Chicago Cubs Predictions 9/22/2021


The Chicago Cubs will look to rebound from their loss against the Twins.  Before this, the Cubs won their series finale against the Brewers but dropped the first two.  Chicago also lost two out of three against the Phillies and was swept by the Giants.  The Cubs have only won two of their last 10 games. Chicago is struggling at the plate posting a .233 batting average which is ranked 28th, and 650 runs scored which dropped to 21st in MLB.  The Cubs’ ERA dropped to 26th at 4.83 and they posted a whip of 1.40 which dropped to 27th in MLB.  Chicago allowed their opponents to bat at an average of .253 which dropped to 23rd in the league.  For Tuesday’s matchup, the Cubs are sending Kyle Hendricks to the hill.  The right-hander is 14-6 with an ERA of 4.81.  Across 170.1 innings of work this season, Hendricks has 190 hits, 91 earned runs, allowed 29 homers, 43 walks, and 123 strikeouts.  


  • The Chicago Cubs are 1-5 SU in its last 6 games at home.
  • The total went UNDER in 4 of the Chicago Cubs’ last 6 games against Minnesota.
  • The total went OVER in 5 of the Chicago Cubs’ last 7 games at home against Minnesota.

Minnesota Twins vs Chicago Cubs. The MLB pick for this game goes to the Minnesota Twins.  The Twins and the Cubs are evenly matched however, the Twins have been playing better recently.  Chicago continues to struggle and has been slipping with continued losses.  The Twins offense was explosive in their last game and this will continue on Wednesday.  Taking the game on the road is the Minnesota Twins.  The final score Prediction is 5-4.  


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Minnesota Twins vs Chicago Cubs 9/22/2021 Picks Predictions Previews

MLB Starting Time: 7:40 PM ET


Location: Wrigley Field, Chicago


Date: Wednesday, September 22, 2021


TV: Marquee Sports


MLB Odds: Chicago Cubs -116


MLB Totals: 8.5


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