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San Francisco 49ers vs Detroit Lions 9/12/2021 Picks Predictions Previews

San Francisco 49ers vs Detroit Lions 9/12/2021 Picks Predictions Previews


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The San Francisco 49ers will battle the Detroit Lions at the Ford Field in Detroit, Michigan on Sunday, September 12, 2021, at 1:00 PM ET. The 49ers rolled through the 2020 season at a record of 6-10. San Francisco finished in fourth place in the NFC West Division. The team defeated the Los Angeles Chargers in the last preseason game to a score of 15-10. Trey Lance notched an interception in his first drive and a coverage sack in his second. JaMycal Hasty went for 58 yards on 19 attempts. Receivers Brandon Aiyuk, Deebo Samuel and Mohammed Sanu received reps with the starters however each dropped a pass across the middle of the field. Aiyuk and Sanu notched an interception from the drops. 


San Francisco has a total of 252.1 passing yards with 118.1 rushing yards. Quarterback Nick Mullens passed for 2,437 yards last year while running back Jeff Wilson Jr. rushed for 600 yards. Wide receiver Brandon Aiyuk had 748 receiving yards. Linebacker Fren Warner led the team’s defense with 125 and cornerback Jamar Taylor intercepted two passes for the team.


  • The San Francisco 49ers are 1-4 SU in their last 5 matches.
  • The 49ers are 10-1 SU in their last 11 matches against Detroit.
  • San Francisco is 12-5 SU in their last 17 matches on the road.

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San Francisco 49ers vs Detroit Lions Predictions 9/12/2021


The Detroit Lions, on the other hand, ended the 2020 season with a 5-11 record, securing fourth place in the NFC North Division. The Lions fell short in the last preseason match against the Buffalo Bills, ending with a 15-16 result. New running back Jamaal Williams went for 15 total yards across nine carries. Craig Reynolds shook multiple tackles and delivered 49 yards on five carries. In the fourth quarter, Reynolds added a 24-yard touchdown run.


The Lions have a total of 256.5 passing yards and 93.7 rushing yards. Quarterback Matthre Stafford passed for 4,084 total yards last year while running back Adrian Peterson rushed for 604 yards. Wide receiver Marvin Jones Jr. had 078 receiving yards. linebacker Jamie Collins Sr. led the team’s defense with 101 tackles. Safety Duran Harmon intercepted two passes for Detroit.


  • The Detroit Lions are 1-6 SU in their last 7 matches.
  • The total went UNDER in 6 of Detroit’s last 9 matches against San Francisco.
  • The Lions are 1-11 SU in their last 12 matches at home.

San Francisco 49ers vs Detroit Lions. The NFL’s pick is the San Francisco 49ers. The team had a terrible record last year but most of its players are off the injury list this year and will take part in the upcoming games. The 49ers have solid quarterbacks this season, which is something Detroit does not have. The Lions did so little during the preseason and will continue to lack in this game. The San Francisco 49ers will win with a predicted score of 30.7-14.


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San Francisco 49ers vs Detroit Lions 9/12/2021 Picks Predictions Previews

NFL Starting Time: 1:00 PM ET


Location: Ford Field 


Date: Sunday, September 12, 2021




NFL Odds: San Francisco 49ers -7.5


NFL Totals: 45


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