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San Francisco 49ers vs Los Angeles Chargers 8/22/2021 Picks Predictions Previews

San Francisco 49ers vs Los Angeles Chargers 8/22/2021 Picks Predictions Previews


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The San Francisco 49ers and the Los Angeles Chargers will meet at the SoFi Stadium in Inglewood, California on Sunday, August 22, 2021, at 7:30 PM EDT. Both teams will play their second preseason activity here. San Francisco finished the 2020 season with a disappointing 6-10 standing. The team came in last in the NFC West standings and they were disqualified from the playoffs. The 49ers lost against Kansas City in the preseason opener and they were three points behind the Chiefs. At halftime of the game, San Francisco was ahead of Kansas City with 9-7 but the team fell by three points in the last minute of the game. Trey Lance had 4 of 14 lines for 128 yards while JaMycal Hasty made 10 carries for 63 yards and one touchdown.


QB Nick Mullens delivered 2,437 passing yards. RB Jess Wilson Jr. rushed 600 yards and WR Brandon Aiyuk has 748 receiving yards. LB Fred Warner notched 125 tackles, leading the defense. CB Jamar Taylor intercepted 2 passes for the team.


  • The San Francisco 49ers are 3-7 ATS in its last 10 matches.

  • San Francisco is 1-5 SU in its last 6 games.

  • The 49ers are 14-5 SU in its last 19 games on the road.

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San Francisco 49ers vs Los Angeles Chargers Predictions 8/22/2021


The Los Angeles Chargers also did not look so well last year. The team finished last season with a record of 7-9 overall. Los Angeles secured third place in the AFC West standings and the Chargers were not also able to participate in the playoffs. The Chargers won their preseason opener against the Rams to an impressive score of 13-6. Chase Daniel has 15 of 24 lines for 104 yards while Larry Rountree made eight carries for 63 yards. Josh Palmer was also able to make six carries for 36 yards.


Los Angeles’ QB Justin Herbert has a total of 4,336 passing yards. RB Austin Ekeler delivered 530 rushing yards while WR Keenan Allen hauled 992 receiving yards. LB Kenneth Murray Jr. leads the team’s defense with 107 tackles. CB Michael Davis has 3 interceptions for the Chargers.


  • The LA Chargers are 5-0 ATS in their last 5 games.

  • The total went UNDER in 5 of the LA Chargers’ last 7 games.

  • The LA Chargers are 5-0 SU in their last 5 games.

San Francisco 49ers vs Los Angeles Chargers. The NFL’s pick is the San Francisco 49ers. The team had a high edge during the opener and San Francisco will manage to put a good game here. The 49ers produced 383 total yards with 66 total plays and 18 first downs. Meanwhile, the Chargers were able to pull off their opener with their good offense. The team made a total of 259 yards on the third and fourth downs with 9 of 17 lines. Take the San Francisco 49ers to bounce back here and win with a predicted score of 21-17.


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San Francisco 49ers vs Los Angeles Chargers 8/22/2021 Picks Predictions Previews

NFL Starting Time: 7:30 PM EDT


Location: SoFi Stadium


Date: Sunday, August 22, 2021




NFL Odds: San Francisco 49ers -5


NFL Totals: 34


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