They kick off Sunday night football from New England at 1PM Eastern Time with national television coverage provided by CBS.
This game is a time change as it was originally scheduled as Sunday night football but switched off prime time due to the Colts poor record.
The point spread opened up in this NFL game with the home team New England Patriots favored by –22 1/2 points with an over under of 48 points.
Early money from the NFL wagering public has landed on the side of the underdog as the New England Patriots are now favored by -20 ½ points.
Over under players will find movement towards the over as the game is now hung at 49 ½ points.
New England Patriots money line bettors will lay –2500 odds with the road underdog Indianapolis Colts bringing back +1400 odds to win straight up with no need for points on their side.
These two AFC conference heavyweights met in 2010 in the regular season and it was the New England Patriots with the 31-28 victory against the Indianapolis Colts as a -4 ½ point betting favorite.
The over under flew well over the closing total of 50 points.
Patriots quarterback Tom Brady had two passing touchdowns in the win while passing for 186 yards.
New England got good production on the ground as BenJarvus Green-Ellis had 96 yards on the ground and Danny Woodhead chipped in with 69 yards.
The New England Patriots offense produced 346 offensive yards on the Colts defense.
Quarterback Peyton Manning hit on 396 yards passing for Indianapolis in the loss.
Veteran running back Donald Brown contributed with 68 yards rushing for the Colts.
The Indianapolis offense moved the ball very well against the New England defense to the tune of 467 offensive yards gained.
The Indianapolis Colts travel to New England with a poor 0-11 record on the season. The team is 0-5 on the highway.
Indy average 13 points and 280 yards per game with 99 yards rushing for 4.4 yards a carry.
On defense the Colts give up 29 points and 389 yards per game. Opponents rush for 150 yards against Indianapolis for 4.2 yards per rush against average.
The team is coming off the 27-19 home loss to the Carolina Panthers last week as a +3 ½ point underdog.
The total came in at under the number of 46 ½ points.
Indy fired their defensively coordinator early in the week following the result.
The Colts put up 323 offensive yards with 105 yards rushing on 23 runs from scrimmage.
The team gave up two sacks and scored one touchdown in three red zone opportunities.
The club had two turnovers and took one from Carolina.
Quarterback Curtis Painter hit on 15 of 29 passes for 226 yards with a touchdown and two interceptions.
Running back Donald Brown had 14 carries for 80 yards and a rushing touchdown.
Joseph Addai on seven rushes ran for 23 yards.
Reggie Wayne led Indy with five receptions for 122 yards and a receiving touchdown.
Pierre Garcon caught three balls for 34 yards.
Austin Collie had three grabs for 28 yards.
The Colts allowed Carolina 377 offensive yards with 201 coming from their run game on 35 rushes.
Indianapolis had three sacks and allowed two Panthers touchdowns in all two red zone tries.
New England returns home with a record of 8-3 on the season. The club is 4-1 at home.
The Patriots put up 30 points and 429 yards per game with 110 yards rushing for 4.1 yards a carry.
On defense New England allows 20 points and 409 yards per game. Teams rush for 102 yards against the Patriots for 4.3 yards per rush against average.
After a two game losing streak the New England Patriots have won three straight games.
New England is coming off the 38-20 home win a week ago to the Philadelphia Eagles as a -3 point betting favorite.
The total went over the closing line of 50 ½ points.
The New England Patriots gained 457 yards of offense with 104 yards rushing on 36 runs from scrimmage.
The team allowed one sack and had four red zone touchdowns in five drives inside the twenty.
New England played turnover free football and took one from Philadelphia.
Quarterback Tom Brady completed 24 of 34 passes for 361 yards with three touchdowns.
Ben Jarvus Green Ellis had 14 rushes for 44 yards and two rushing touchdowns.
Danny Woodhead had 20 rushing yards on four carries.
Shane Vereen saw seven rushes and ran for 18 yards.
Deion Branch led New England with six receptions for 125 yards.
Wes Welker had eight catches for 115 yards.
Tight end Aaron Hernandez grabbed six balls for 62 yards.
Rob Gronkowski had a touchdown catch to go with his four catches for 59 yards.
The Patriots allowed Philadelphia 466 yards of offense with 73 coming on the ground on 17 runs from scrimmage.
New England had two sacks and gave up two Eagles touchdown in four red zone appearances.
NFL Trend: Indianapolis Colts are 0-7 ATS in their past seven games.